Diesel and gasoline engine exhausts and some nitroarenes / this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans which met in Lyon, 1-8 March 1988.
Material type:
TextSeries: IARC monographs on the evaluation of carcinogenic risks to humans ; v. 46Publication details: Lyon : International Agency for Research on Cancer, 1989. Description: 458 pISBN: 9283212460Subject(s): Vehicle emissions -- adverse effects -- analysis | Nitro compounds -- adverse effects | Carcinogens, Environmental | Chemical Toxicology and CarcinogenicityNLM classification: QZ 202Abstract: Evaluates the carcinogenic risk to humans posed by exposure to exhausts from diesel and gasoline engines of vehicles. Evaluations incorporate the consensus reached by a group of 22 experts commissioned to review the complete body of evidence relating exposure to engine exhausts to the risk of cancer in humans. Particular attention is given to the possibility that exposure to respirable particles emitted by engines can cause tumours of the lung or bladder or induce changes that contribute to the risk of childhood cancers. Because of differences in the characteristics of exhausts from different types of motors and different types of fuel, diesel and gasoline exhausts are evaluated separately. Separate carcinogenicity evaluations are also provided for 15 nitroarenes found in engine exhausts and produced in considerable amounts by diesel engines. The monograph on gasoline and diesel exhausts opens with a brief review of methodological problems that can influence the interpretation of data. Readers are reminded that the composition and quantity of emissions from an engine depend on the type and condition of the engine, fuel composition and additives, operating conditions, and emission control devices such as catalytic converters. A section concerned with occupational exposure considers higher exposures to engine exhausts occurring in such occupations as transportation and garage work, underground mining, vehicle maintenance and examination, traffic control, logging, firefighting, and heavy equipment operation. The most extensive section evaluates the design and findings of the large number of animal studies concerned with the carcinogenicity and mutagenicity of engine exhausts and their individual components. Other data reviewed come from research in experimental systems, experimental work in human volunteers, and epidemiological studies. On the basis of this review, the experts conclude that there is sufficient evidence for the carcinogenicity in experimental animals of whole diesel engine exhaust, of extracts of diesel engine exhaust particles, and of condensates/extracts of gasoline engine exhaust. Diesel engine exhaust is classified as probably carcinogenic to humans, and gasoline engine exhaust as possibly carcinogenic to humans. The second half of the book presents separate monographs for 15 nitroarenes found in engine exhausts. Of these, six were judged to be possibly carcinogenic to humans. The remaining nitroarenes could not be classified on the basis of currently available data.
| Item type | Current library | Call number | Copy number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
Books
|
WHO HQ READING-RM | IARC SERIAL (Browse shelf(Opens below)) | 1 | Available | 00021813 | |
|
Books
|
WHO HQ BORROWABLE-COLL-STACKS | QZ 202 89IA-1 (Browse shelf(Opens below)) | 2 | Available | 00021814 |
Browsing WHO HQ shelves, Shelving location: BORROWABLE-COLL-STACKS Close shelf browser (Hides shelf browser)
| QZ 202 88OC Occupational cancer : | QZ 202 88PR Unusual occurrences as clues to cancer etiology : | QZ 202 89IA Occupational exposures in petroleum refining : | QZ 202 89IA-1 Diesel and gasoline engine exhausts and some nitroarenes / | QZ 202 89IA-2 Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting / | QZ 202 89PA Palliative cancer care : | QZ 202 89PE Perinatal and multigeneration carcinogenesis / |
Evaluates the carcinogenic risk to humans posed by exposure to exhausts from diesel and gasoline engines of vehicles. Evaluations incorporate the consensus reached by a group of 22 experts commissioned to review the complete body of evidence relating exposure to engine exhausts to the risk of cancer in humans. Particular attention is given to the possibility that exposure to respirable particles emitted by engines can cause tumours of the lung or bladder or induce changes that contribute to the risk of childhood cancers. Because of differences in the characteristics of exhausts from different types of motors and different types of fuel, diesel and gasoline exhausts are evaluated separately. Separate carcinogenicity evaluations are also provided for 15 nitroarenes found in engine exhausts and produced in considerable amounts by diesel engines. The monograph on gasoline and diesel exhausts opens with a brief review of methodological problems that can influence the interpretation of data. Readers are reminded that the composition and quantity of emissions from an engine depend on the type and condition of the engine, fuel composition and additives, operating conditions, and emission control devices such as catalytic converters. A section concerned with occupational exposure considers higher exposures to engine exhausts occurring in such occupations as transportation and garage work, underground mining, vehicle maintenance and examination, traffic control, logging, firefighting, and heavy equipment operation. The most extensive section evaluates the design and findings of the large number of animal studies concerned with the carcinogenicity and mutagenicity of engine exhausts and their individual components. Other data reviewed come from research in experimental systems, experimental work in human volunteers, and epidemiological studies. On the basis of this review, the experts conclude that there is sufficient evidence for the carcinogenicity in experimental animals of whole diesel engine exhaust, of extracts of diesel engine exhaust particles, and of condensates/extracts of gasoline engine exhaust. Diesel engine exhaust is classified as probably carcinogenic to humans, and gasoline engine exhaust as possibly carcinogenic to humans. The second half of the book presents separate monographs for 15 nitroarenes found in engine exhausts. Of these, six were judged to be possibly carcinogenic to humans. The remaining nitroarenes could not be classified on the basis of currently available data.
eng.
WHODOC
WHO monograph
4
There are no comments on this title.