MARC details
| 000 -LEADER |
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| fixed length control field |
02768cam a2200289 4500 |
| 001 - CONTROL NUMBER |
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| control field |
9241571225 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9241571225 |
| 035 ## - |
|---|
| -- |
(Sirsi) 9241571225 |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
QV 633 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
910530s1991 1 0 eng |
| 245 02 - TITLE STATEMENT |
|---|
| Title |
n-Hexane / |
| Statement of responsibility, etc. |
published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Geneva : |
| Name of publisher, distributor, etc. |
World Health Organization, |
| Date of publication, distribution, etc. |
1991. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
164 p. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Environmental health criteria ; |
| Volume/sequential designation |
122 |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Summary and chapters 10, 11 and 12 in French and Spanish. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Evaluates the risks to human health and the environment posed by n-hexane, a chemical isolated from natural gas and crude oil and used in food processing to extract vegetable oil from beans, nuts, and seeds. n-Hexane is also used as a solvent, a cleaning agent, in the rubber industry, and in the manufacture of pharmaceuticals. The opening sections review what is known about the behaviour of this highly volatile chemical in the environment and its metabolic fate in experimental animals and in the human body. A review of investigations in experimental animals and in vitro test systems concentrates on testicular lesions and neurotoxicity as the principal effects of repeated exposure to n-hexane. Studies have also shown that neurotoxicity induced by n-hexane is enhanced by co-exposure to methyl ethyl ketone, methyl isobutyl ketone, and lead acetate; co-exposure to toluene decreases the neurotoxic effects of n-hexane. These findings are further supported by observations in humans, which draw upon several reports of peripheral neuropathy in workers exposed to n-hexane and in abusers of glues or solvents containing this chemical. The report notes that the majority of occupational cases have occurred in poorly ventilated small industries. While concluding that n-hexane is not likely to present a hazard to either the general population or the environment, the report stresses the need for precautions in the occupational setting, including the use of suitably designed work processes and engineering controls for reducing atmospheric levels below the recommended occupational exposure limits. The book further recommends the use of protective clothing and the ready availability of respiratory protection for use in enclosed spaces and in emergencies. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
eng. |
| 550 ## - ISSUING BODY NOTE |
|---|
| Issuing body note |
WHODOC |
| 561 ## - OWNERSHIP AND CUSTODIAL HISTORY |
|---|
| History |
WHO monograph |
| 596 ## - |
|---|
| -- |
4 |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Hexanes |
| General subdivision |
adverse effects |
| -- |
toxicity. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Environmental exposure. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) |
|---|
| Topical term or geographic name as entry element |
Chemical Toxicology and Carcinogenicity. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
International Programme on Chemical Safety. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
NLM Classification Scheme |
| Koha item type |
Books |
