MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02817cam a2200301 4500 |
| 001 - CONTROL NUMBER |
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| control field |
924157156X |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
924157156X |
| 035 ## - |
|---|
| -- |
(Sirsi) 924157156X |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QD 305.H7 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
940620s1994 1 0 eng |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Hexachlorobutadiene / |
| Statement of responsibility, etc. |
published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Geneva : |
| Name of publisher, distributor, etc. |
World Health Organization, |
| Date of publication, distribution, etc. |
1994. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
136 p. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Environmental health criteria ; |
| Volume/sequential designation |
156 |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Summary and evaluation; conclusions and recommendations also in French and Spanish. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Evaluates risks to human health and the environment posed by exposure to hexachlorobutadiene. This compound is essentially a waste product formed during the manufacturing of various chlorinated hydrocarbons. Hexachlorobutadiene has limited use as an agricultural fumigant in some parts of the world. The chemical can also be used for the recovery of chlorine-containing gas in chlorine plants and as a wash liquor for removing certain volatile organic compounds from gas streams. A review of experimental studies concentrates on the large body of evidence demonstrating short- and long-term effects on the kidney. These findings support the conclusion that the target organs for toxicity, in humans as well as experimental animals, are the kidney, and to a much lesser extent, the liver. The report also cites evidence supporting the hypothesis that the nephrotoxicity, mutagenicity, and carcinogenicity of hexachlorobutadiene are dependent on the biosynthesis of a reactive sulfur metabolite following conjugation with glutathione. In view of the shortage of human studies, the evaluation of effects on health draws upon experimental data supported by evidence that the metabolism of hexachlorobutadiene is similar in humans and animals. The report concludes that hexachlorobutadiene should be regarded as a sensitizing agent. Evidence for carcinogenicity is limited in animals and insufficient in humans. Concerning risks to the environment, the report concludes that aquatic animals may be at risk in polluted surface waters. In view of the toxicity of hexachlorobutadiene to mammals and its high potential to bioaccumulate, the consumption of benthic or aquatic organisms in polluted surface water by other species may constitute an additional cause for concern. |
| 535 ## - |
|---|
| -- |
DC.HQ |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
eng. |
| 550 ## - ISSUING BODY NOTE |
|---|
| Issuing body note |
WHODOC |
| 561 ## - OWNERSHIP AND CUSTODIAL HISTORY |
|---|
| History |
WHO monograph |
| 596 ## - |
|---|
| -- |
4 |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Butadienes |
| General subdivision |
toxicity. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Environmental exposure. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) |
|---|
| Topical term or geographic name as entry element |
Chemical Toxicology and Carcinogenicity. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
International Programme on Chemical Safety. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
NLM Classification Scheme |
| Koha item type |
Books |
