MARC details
| 000 -LEADER |
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| fixed length control field |
04957cam a2200325 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9241208244 |
| 035 ## - |
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| -- |
(Sirsi) a41575 |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
WC 550 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
920925s1992 1 0 eng |
| 110 2# - MAIN ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
WHO Expert Committee on Rabies. |
| 242 10 - TRANSLATION OF TITLE BY CATALOGING AGENCY |
|---|
| Title |
Comité OMS d' experts de la rage [réuni à Genève du 24 au 30 septembre 1991] : |
| Remainder of title |
huitième rapport |
| 242 10 - TRANSLATION OF TITLE BY CATALOGING AGENCY |
|---|
| Title |
Comité de Expertos de la OMS sobre Rabia [se reunió en Ginebra del 24 al 30 de septiembre 1991] : |
| Remainder of title |
octavo informe |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
WHO Expert Committee on Rabies [meeting held in Geneva from 24 to 30 September 1991] : |
| Remainder of title |
eighth report. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Geneva : |
| Name of publisher, distributor, etc. |
World Health Organization, |
| Date of publication, distribution, etc. |
1992. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
84 p. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
WHO technical report series ; |
| Volume/sequential designation |
824 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Evaluates new knowledge from basic and applied research on rabies in terms of its relevance to the prevention and control of this disease. Noting the many new tools now available for both clinical and field application, the report issues advice and recommendations intended to help national control authorities bring their policies - whether concerning first-choice vaccines or procedures for quarantine - in line with the latest scientific knowledge. The report also identifies specific research problems that need to be solved in the drive to develop more sensitive diagnostic techniques, to improve the immunogenicity and cost-effectiveness of vaccines, and to eliminate rabies in canine and wild animal populations. Information is presented in eleven sections. The first reviews recent advances in rabies research, including progress in understanding the molecular structure and genetics of lyssaviruses, significant strides forward in methods for the production and delivery of vaccines, the development of several unique recombinant vaccines, and the potential use substances such as monoclonal antibodies, interferon, and interferon-inducers for post-exposure treatment. The second section, devoted to diagnosis, evaluates existing and evolving techniques for diagnosis in animals and humans and for the characterization of virus strains. Recent improvements in human and veterinary rabies vaccines are reviewed in the third section, which features extensive information on the quality controls that must be followed during production and the safety and potency tests that must be performed on each vaccine batch before its release. The report also strongly recommends that encephalitogenic vaccines derived from brain tissue be replaced, as soon as possible, with vaccines prepared in cell culture. Other sections bring readers up-to-date on the status of WHO reference materials for potency testing of vaccines and immunoglobulins, and outline procedures for the licensing and testing, prior to release, of inactivated tissue culture vaccines. In view of the extremely high fatality rate of human rabies, information on prevention is especially detailed. Practical advice includes recommended immunization schedules for the prtection of individuals at high risk of exposure, guidelines for post-exposure treatment, and an explanation of the factors to consider when deciding whether or not to initiate post-exposure treatment. The treatment of confirmed rabies in humans, although almost inevitably fatal, is also briefly discussed. Strategies for rabies prevention are further detailed in sections describing new approaches to the control of rabies in dogs and wild animal populations. Drawing upon lessons learned in several large mass immunization campaigns, the report explains how the recently developed oral vaccination technique can be used to control the disease in foxes, racoons, other wild animals, and possibly also in dogs. The report further concludes that the removal and destruction of dogs and wildlife should no longer be carried out on a large scale, as such an approach has never been shown to have a significant, long-term impact on either population densities or the spread of rabies. The final main section issues recommendations, in line with new knowledge, for the international transfer of animals, including guidelines for the possible reduction of quarantine procedures and a recommended special exemption for guide dogs for the blind. Further practical advice is set out in a series of eight annexes, which provide guidelines for the testing of vaccines, post-exposure treatment, the format of vaccination certificates, the use of a standard reporting form to record data on exposed humans, and the design of a national programme for the control of rabies in dogs. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
eng fre rus spa. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
nep por. |
| 550 ## - ISSUING BODY NOTE |
|---|
| Issuing body note |
WHODOC |
| 561 ## - OWNERSHIP AND CUSTODIAL HISTORY |
|---|
| History |
WHO monograph |
| 596 ## - |
|---|
| -- |
4 |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Rabies. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Rabies vaccines. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) |
|---|
| Topical term or geographic name as entry element |
Veterinary Public Health and Zoonoses. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://apps.who.int/iris/">https://apps.who.int/iris/</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://apps.who.int/iris/">https://apps.who.int/iris/</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
NLM Classification Scheme |
| Koha item type |
Books |
