MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02902cam a2200337 4500 |
| 001 - CONTROL NUMBER |
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| control field |
9241571551 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9241571551 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
5225032605 (Russian) |
| 035 ## - |
|---|
| -- |
(Sirsi) 9241571551 |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
QH 541.15.B615 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
940315s1993 1 0 eng |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Biomarkers and risk assessment : |
| Remainder of title |
concepts and principles / |
| Statement of responsibility, etc. |
published under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Geneva : |
| Name of publisher, distributor, etc. |
World Health Organization, |
| Date of publication, distribution, etc. |
1993. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
82 p. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Environmental health criteria ; |
| Volume/sequential designation |
155 |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Summary and recommendations in French and Spanish. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
A guide to the concepts and principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection and validation of appropriate biomarkers of exposure, of toxic effect, and of susceptibility in either individuals or sub-populations. The book also explains how the use of validated biomarkers to monitor exposed populations can provide the basis for early public health interventions. The book opens with background information on the uses of biomarkers for health risk assessment, clinical diagnosis, and the monitoring of exposure, followed by a discussion of the principles and methods governing their selection and validation. The ethical and social issues that need to be considered when designing research projects are also discussed. The main part of the book sets out guidelines, supported by examples from recent research, for the selection and use of biomarkers of exposure, of effect, of carcinogenicity, and of susceptibility. For biomarkers of effect, the book concentrates on biomarkers that are currently used or under development to assess toxic effects on the hepatic, renal, haematological, immune, pulmonary, reproductive, developmental and nervous systems. For biomarkers of genotoxic carcinogens, the book describes currently available techniques using DNA adducts, protein adducts, cytogenic methods, chromosome damage, sister chromatid exchange, micronuclei, aneuploidy, and mutation. Biomarkers for non-genotoxic carcinogens are also briefly discussed. The concluding chapter, on susceptibility, alerts researchers to the many factors that can affect individual susceptibility to the toxic effects of chemicals. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
eng rus. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
jpn pol. |
| 550 ## - ISSUING BODY NOTE |
|---|
| Issuing body note |
WHODOC |
| 561 ## - OWNERSHIP AND CUSTODIAL HISTORY |
|---|
| History |
WHO monograph |
| 596 ## - |
|---|
| -- |
4 |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Biological markers. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Environmental exposure. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Hazardous substances. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Risk factors. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) |
|---|
| Topical term or geographic name as entry element |
Chemical Toxicology and Carcinogenicity. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
International Programme on Chemical Safety. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
NLM Classification Scheme |
| Koha item type |
Books |
