000			03355cam a2200289 4500
001			9290211709
020			_a9290211709
035			_a(Sirsi) 9290211709
060			_aWC 200
100	1		_aAbou, Yousif Z.
245	0	0	_aGuide to chemotherapy and chemoprophylaxis in bacterial infections / _cby Yousif Z. Abou, Ala'din A. S. Alwan.
260			_aAlexandria : _bWHO Regional Office for the Eastern Mediterranean , _c1993.
300			_a125 p.
440		0	_aWHO regional publications. _pEastern Mediterranean series _v4
520	3		_aA comprehensive guide to the rational and safe prescribing of antimicrobials in the treatment and prevention of bacterial infections. Particular emphasis is given to the management of infections commonly found in Eastern Mediterranean countries. Addressed to physicians, the guide responds to the urgent need to prevent the misuse of antibiotics, protect against the emergence of resistant bacterial strains, and reduce the waste of resources spent on useless treatments. Both the principles and the specifics of good prescribing practice are covered in detail. The manual has five chapters. The first explains the general principles of safe and effective antimicrobial therapy, emphasizing the many factors that need to be considered when selecting drugs, doses, and modes of administration. Information ranges from an outline of factors responsible for the failure of antimicrobial therapy, to advice on the treatment of infections in the compromised host, from the simple reminder that frequent use of antimicrobial combinations points to imprecise diagnosis, to a tabular presentation of 19 antimicrobials having adverse effects, the precautions to be followed, and contraindications. The second chapter, which constitutes the core of the manual, provides precise prescribing guidelines for the management of 77 bacterial infections. For each infection, information includes relevant diagnostic advice, the most likely causative organisms listed in the order of frequency, the first-choice drug or combination, followed by alternatives, and advice on dosage, mode of administration, and duration of therapy. Cases where antibiotics are useless or contraindicated are clearly stated. The chapter also includes information on the general properties and most appropriate uses of eight general categories of first-choice drugs. The third chapter outlines essential information about the properties, advantages, and limitations of topical preparations for use as disinfectants, antiseptics, cleaning agents, and antibiotics. Chemoprophylaxis is covered in the fourth chapter, which describes indications for chemoprophylaxis to prevent wound infection and sepsis in surgery, to prevent selected infections, and to prevent bacterial endocarditis. The concluding chapter set out dosage ranges - for adults, children, neonates, and patients with renal impairment - for 25 commonly used antimicrobials.
535			_aDC.EMRO
546			_aeng.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aBacterial infections _xdrug therapy.
690			_aCommunicable Diseases and their Control.
700	1		_aAlwan, Ala'din.
710	2		_aWorld Health Organization. _bRegional Office for the Eastern Mediterranean.
008			931111s1993 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c9032 _d9032