000			02788cam a2200289 4500
001			924157142X
020			_a924157142X
035			_a(Sirsi) 924157142X
060			_aWA 240
245	0	0	_aAlpha-cypermethrin / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1992.
300			_a112 p.
440		0	_aEnvironmental health criteria ; _v142
500			_aSummary and evaluation, conclusions and recommendations in French and Spanish.
520	3		_aEvaluates risks to human health and the environment posed by the use of alpha-cypermethrin, a potent and versatile pyrethroid insecticide used against a wide range of pests encountered in agriculture. Main agricultural applications include the protection of oilseeds, pome fruits, peaches, fruiting vegetables, berries, leafy vegetables, maize, hops, and tobacco. Marketed since late 1983, alpha-cypermethrin is also used against disease-carrying insects and in the control of parasites of veterinary importance. In view of the uses of this pesticide, an evaluation of sources of human exposure draws upon crop residue data obtained from a large number of supervised trials conducted throughout the world. The report concludes that exposure of the general population is negligible when the pesticide is used in keeping with good agricultural practice. Toxicity studies conducted in laboratory mammals and in vitro test systems indicate that alpha-cypermethrin has a moderate to high acute oral toxicity and is 34 times more toxic than cypermethrin. Short-term exposures have not been shown to cause toxic effects. Several studies provide evidence that alpha-cyper-methrin is non-mutagenic. No data on long-term toxicity, teratogenicity, carcinogenicity, or immunotoxicity were available for evaluation. The report concludes that, when good work practices, hygiene measures, and safety precautions are followed, use of alpha-cypermethrin is unlikely to pose a hazard to occupationally exposed workers. Though laboratory studies have documented high toxicity for fish, studies show that this toxicity is not realized under field conditions, where the rapid loss of alpha-cypermethrin from water facilitates the complete recovery of affected populations.
546			_aeng.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aEnvironmental exposure.
650	0	2	_aPyrethrins _xadverse effects _xtoxicity.
690			_aChemical Toxicology and Carcinogenicity.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			930121s1992 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c14039 _d14039