000			03213cam a2200313 4500
001			9241571160
020			_a9241571160
035			_a(Sirsi) 9241571160
060			_aQV 290
245	0	0	_aTributyltin compounds / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organizaton ; first draft prepared by S. Dobson.
260			_aGeneva : _bWorld Health Organization, _c1990.
300			_a273 p.
440		0	_aEnvironmental health criteria ; _v116
500			_aTranslation in French and Spanish of chapters 1, 13, and 14.
520	3		_aEvaluates risks to human health and the environment posed by the use of tributyltin compounds as molluscicides, as antifoulants on boats, ships, quays, buoys, and equipment in the fishing industry, as wood preservatives, and as slimicides on masonry. Tributyltin compounds are also used as biocides for cooling systems, power station cooling towers, pulp and paper mills, textile mills, and breweries. These compounds pose a particular threat to the marine environment in view of their documented high toxicity to aquatic organisms, including commercially important shellfish. A discussion of sources of environmental exposure concentrates on various national bans and restrictions introduced following evidence that use of these compounds in antifouling paints was responsible for a complete failure of the French oyster industry in the late 1970s. The review also notes that concentrations exceeding those producing acute lethal effects have been found worldwide in many different locations, most frequently associated with pleasure boating activities. Toxic effects on organisms in the environment are thoroughly evaluated in separate chapters dealing with algae and other micro-organisms, aquatic organisms, and terrestrial organisms. Tributyl compounds are observed to be toxic to microorganisms and highly toxic to oysters, mussels, and other marine molluscs consumed by humans. A review of field observations, which are in good agreement with laboratory findings, confirms the association between use of these compounds in the marine environment and mortality, malformations, and population decline of molluscs. The remaining sections evaluate findings from experimental studies and observations in occupationally exposed humans. The book concludes that tributyltin compounds are a severe irritant to human skin and an extreme irritant to the eye, and that inhalation of aerosols can have especially hazardous effects on the respiratory trac. Despite the large body of studies documenting toxicity, the book was unable to quantify the risk to humans posed by the consumption of contaminated fish and shellfish.
546			_aeng.
546			_ajpn.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aTrialkyltin compounds.
690			_aChemical Toxicology and Carcinogenicity.
700	1		_aDobson, Stuart.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
856			_uhttps://apps.who.int/iris/
008			910125s1990 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c13640 _d13640