000			02894cam a2200313 4500
001			9241571101
020			_a9241571101
035			_a(Sirsi) 9241571101
060			_aQV 627
245	0	0	_aTricresyl phosphate / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1990.
300			_a122 p.
440		0	_aEnvironmental health criteria ; _v110
500			_aTranslations in French and Spanish of: chapters 1, 10 and 11.
520	3		_aEvalutes risks to human health and the environment posed by the production and use of tricresyl phosphate. Tricresyl phosphate is used in industry as a plasticizer in vinyl plastic manufacture, as a flame-retardant, as a solvent for nitrocellulose, in cellulosic molding compositions, and in the manufacture of fire-resistant hydraulic fluids and lubricants. Because of the physico-chemical properties of tricresyl phosphate and its rapid biodegradation, the report concludes that use of the compound does not threaten the environment, though there is some evidence that crop plants can be affected by tri-o-cresyl phosphate released from plastic coverings. A section devoted to kinetics and metabolism concentrates on mechanisms of absorption, distribution, metabolism, and elimination that can help explain the well-documented neuropathic actions of tricresyl phosphate and, most notably, its highly toxic isomer, tri-o-cresyl phosphate. The most extensive section assesses findings from toxicity studies, emphasizing the large number of studies documenting neurotoxic effects, often at very low doses. These effects are further characterized through a review of the numerous reported cases of large-scale human poisoning following the ingestion of accidentally or deliberately contaminated medicines and foodstuffs. Readers are given detailed information on the clinical symptoms of poisoning, the characteristics of delayed neuropathy, long-term prognosis, and advice on the first-aid treatment of victims. While the concluding section notes that use of tricresyl phosphate poses very little risk to either the environment or the general population, the report underscores the severity and long-duration of the neuropathology caused by accidental poisoning, noting that some victims never recover.
546			_aeng.
546			_ajpn.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aTritolyl phosphates _xadverse effects _xtoxicity.
650	0	2	_aEnvironmental exposure.
650	0	2	_aEnvironmental pollutants.
690			_aChemical Toxicology and Carcinogenicity.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			910115s1990 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c13544 _d13544