000			02093cam a2200277 4500
001			9241542756
020			_a9241542756
035			_a(Sirsi) 9241542756
060			_aQD 341.H9
245	0	0	_aToluene diisocyanates / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1987.
300			_a72 p.
440		0	_aEnvironmental health criteria ; _v75
520	3		_aExamines the methodology and findings of over 150 published studies in an effort to determine the risks to human health and the environment posed by the two isomers of toluene diisocyanate. These synthetic organic chemicals are important industrial intermediates used in conjunction with polyether and polyester polyols as co-reactants in the manufacture of polyurethane foams, paints, varnishes, elastomers, and coatings. A section devoted to effects on experimental animals and in vitro test systems considers toxic effects observed for single exposures, short-term exposures, and long-term exposures via inhalation, dermal application, and oral gavage. In view of the wide use of these compounds by a large number of workers, the section devoted to effects on man uses findings from epidemiological studies to document the extent and severity of gastrointestinal, neurological, ocular, dermal, and respiratory symptoms. On the basis of available data, the book concludes that the isomers of toluene diisocyanate should be classified as very toxic compounds by inhalation, and that they should be treated as potential human carcinogens and as known animal carcinogens.
546			_aeng.
546			_apol.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aToluene 2,4-diisocyanate.
690			_aPharmacology, Toxicology and Clinical Technology.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			880216s1987 eng
942			_2NLM _cMONOGRAPH
999			_c13251 _d13251