000			01902cam a2200265 4500
001			9241542748
020			_a9241542748
035			_a(Sirsi) 9241542748
060			_aQU 60
245	0	0	_aDiaminotoluenes / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1987.
300			_a67 p.
440		0	_aEnvironmental health criteria ; _v74
520	3		_aEvaluates the risks to human health and the environment posed by diaminotoluenes. Classed as toxic, highly irritant chemicals, diaminotoluenes are large-volume intermediates used in the production of a wide variety of industrial and consumer products, ranging from dyes and corrosion inhibitors to photographic developers. The most extensive section considers the design and findings of studies conducted in experimental animals and in vitro test systems. A review of toxic effects observed with different exposures is followed by an analysis of data demonstrating that diaminotoluenes impair spermatogenesis in experimental animals and are embryotoxic and teratogenic. Documented effects on man include severe dermatitis, blistering, and urticaria and, in the eye, lachrymation, corneal opacities, and permanent blindness, if untreated. The book concludes that diaminotoluenes should be handled as hazardous chemicals and that preventive measures should be taken to protect workers and avoid environmental pollution.
546			_aeng.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aPhenylenediamines.
690			_aPharmacology, Toxicology and Clinical Technology.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			880216s1987 eng
942			_2NLM _cMONOGRAPH
999			_c13250 _d13250