000			03077cam a2200313 4500
001			9241571411
020			_a9241571411
020			_a522503246x (Russian)
035			_a(Sirsi) 9241571411
060			_aQV 602
245	0	0	_aQuality management for chemical safety testing / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1992.
300			_a112 p.
440		0	_aEnvironmental health criteria ; _v141
520	3		_aA highly detailed guide to the principles and specifics of quality management needed to ensure that studies of chemical safety produce accurate and meaningful results. Focused on the management of both the laboratory and the individual studies it conducts, the book stresses the need to establish and follow formal standard procedures for virtually every laboratory practice that can influence the quality of study results. The objective is to help laboratory managers and staff think through all possible sources of error and plan appropriate measures for their control. Details range from a list of the types of records that must be kept to a description of the precautions needed to make certain that chemicals used for cleaning or pest control in animal rooms do not interfere with the study. The book has three chapters. The first provides a guide to the principles of management and organization required for quality assurance, stressing the importance of making quality assurance an itegral part of the entire study process. To this end, readers are given advice on the selection and training of personnel, the use of inspections and audits, the design of facilities, the maintenance and calibration of equipment, and the formulation and use of written standard operating procedures. Other sections give detailed advice on the quality management of specific laboratory routines and procedures, moving from the preparation of the study plan, through the characterization of test, control, and reference substances, to the reporting of results. The second chapter explains how quality management can be applied to procedures for handling animals at all stages of a toxicity study, from the shipping and receipt of animals to the transfer of tissues and specimens to archives. The final chapter covers the quality control of studies designed to measure the presence of chemicals in humans and the environment, and to monitor the extent and effects of exposure.
546			_aeng (with summaries in fre and spa, rus) rus.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aHazardous substances _xtoxicity.
650	0	2	_aLaboratories _xstandards.
650	0	2	_aQuality control.
650	0	2	_aToxicology _xmethods.
690			_aChemical Toxicology and Carcinogenicity.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			921029s1992 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c13078 _d13078