000			02353cam a2200349 4500
001			9241542594
020			_a9241542594
035			_a(Sirsi) 9241542594
060			_aWA 30
245	0	0	_aPrinciples for evaluating health risks from chemicals during infancy and early childhood : _bthe need for a special approach / _cpublished under the joint sposorship of the United Nations Environment Programme, the International Labour Organisation, the World Health Organization, and on behalf of the Commission of the European Communities.
260			_aGeneva : _bWorld Health Organization, _c1986.
300			_a73 p.
440		0	_aEnvironmental health criteria ; _v59
500			_achi of nos. 35, 36, 37, 38, 46, 47 and 59 published in one volume by: Beijing : Chinese Academy of Preventive Medicine.
502			_aBibliography: p.53-66.
520	3		_aElaborates basic principles for the evaluation of chemical toxicology that are specific to the physiological characteristics of infants and young children. Principles of evaluation, which were worked out by 46 leading experts, are based on a thorough review of data on postnatal physiology, metabolism, and the special factors governing exposure in this age group, including behavioural and cultural conditions. Following background information on relevant features of postnatal morphology, biochemistry, and physiology, chapters assess the kinetics of absorption, biotransformation, and elimination and point out ways in which certain conditions of postnatal development will influence the effects of chemicals on different organs and systems. The book concludes with a discussion of factors that can assist in the identification of children at risk.
546			_aeng.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aChemicals _xadverse effects _xin infancy and childhood.
650	0	2	_aHealth status indicators.
650	0	2	_aEnvironmental exposure.
690			_aPharmacology, Toxicology and Clinical Technology.
710	2		_aInternational Programme on Chemical Safety.
710	2		_aCommission of the European Communities.
710	2		_aUnited Nations Environment Programme.
710	2		_aInternational Labour Organization.
710	2		_aWorld Health Organization.
008			860707s1986 eng
942			_2NLM _cMONOGRAPH
999			_c12109 _d12109