000			02944cam a2200289 4500
001			9241542888
020			_a9241542888
020			_a5225019226 (Russian)
035			_a(Sirsi) 9241542888
060			_aQV 633
245	0	0	_aPolychlorinated dibenzo-para-dioxins and dibenzofurans / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1989.
300			_a409 p.
440		0	_aEnvironmental health criteria ; _v88
500			_aSummary, evaluation and recommendations in French and Spanish.
520	3		_aEvaluates the risks to human halth and the environment posed by exposure to polychlorinated dibenzo-para-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). These compounds, which are not produced intentionally, are formed as an undesired side reaction during the manufacture of a number of chemical products used extensively as insecticides, herbicides, fungicides, mold inhibitors, antiseptics, disinfectants, and wood preservatives. These compounds are also unintentionally formed during a variety of incineration reactions. A section devoted to sources of environmental pollution traces most of the presence of these compounds in the environment to the use of contaminated chemicals and, most notably, to products prepared from 2,4,5-trichlorophenol. Particular attention is given to incidents of heavy environmental pollution resulting from industrial accidents, as occurred at a factory near Seveso in Northern Italy, from improper disposal of industrial waste, as occurred in Missouri and in Love Canal, USA, and from the heavy use of contaminated chemicals, as occurred at a US Air Force base during the testing of aerial spraying equipment for operations using Agent Orange. The greatest part of the book evaluates the extensive body of data linking these compounds, and especially the PCDD 2,3,7,8-tetrachloro-dibenzo-p-dioxin, to adverse effects on health. The assessment also draws upon studies following industrial accidents, mass outbreaks of poisoning caused by consumption of contaminated rice oil in Japan and Taiwan, and the widespread use of contaminated Agent Orange in Viet Nam. Despite the number of clinical and follow-up studies, and despite the high incidence of hepatocellular carcinoma observed in some animal species, the report concludes that, for occupational and accidental exposures, no clear-cut persistent systemic effects other than chloracne have been observed. Uncertain.
546			_aeng rus.
546			_ajpn.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aDioxins _xadverse effects _xtoxicity.
650	0	2	_aBenzofurans _xadverse effects _xtoxicity.
690			_aChemical Toxicology and Carcinogenicity.
008			900723s1989 0 eng
942			_2NLM _cMONOGRAPH
999			_c12021 _d12021