000			02902cam a2200337 4500
001			9241571551
020			_a9241571551
020			_a5225032605 (Russian)
035			_a(Sirsi) 9241571551
060			_aQH 541.15.B615
245	0	0	_aBiomarkers and risk assessment : _bconcepts and principles / _cpublished under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1993.
300			_a82 p.
440		0	_aEnvironmental health criteria ; _v155
500			_aSummary and recommendations in French and Spanish.
520	3		_aA guide to the concepts and principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection and validation of appropriate biomarkers of exposure, of toxic effect, and of susceptibility in either individuals or sub-populations. The book also explains how the use of validated biomarkers to monitor exposed populations can provide the basis for early public health interventions. The book opens with background information on the uses of biomarkers for health risk assessment, clinical diagnosis, and the monitoring of exposure, followed by a discussion of the principles and methods governing their selection and validation. The ethical and social issues that need to be considered when designing research projects are also discussed. The main part of the book sets out guidelines, supported by examples from recent research, for the selection and use of biomarkers of exposure, of effect, of carcinogenicity, and of susceptibility. For biomarkers of effect, the book concentrates on biomarkers that are currently used or under development to assess toxic effects on the hepatic, renal, haematological, immune, pulmonary, reproductive, developmental and nervous systems. For biomarkers of genotoxic carcinogens, the book describes currently available techniques using DNA adducts, protein adducts, cytogenic methods, chromosome damage, sister chromatid exchange, micronuclei, aneuploidy, and mutation. Biomarkers for non-genotoxic carcinogens are also briefly discussed. The concluding chapter, on susceptibility, alerts researchers to the many factors that can affect individual susceptibility to the toxic effects of chemicals.
546			_aeng rus.
546			_ajpn pol.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aBiological markers.
650	0	2	_aEnvironmental exposure.
650	0	2	_aHazardous substances.
650	0	2	_aRisk factors.
690			_aChemical Toxicology and Carcinogenicity.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			940315s1993 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c11944 _d11944