000			02803cam a2200277 4500
001			9241542942
020			_a9241542942
020			_a5225018971 (Russian)
035			_a(Sirsi) 9241542942
060			_aWA 240
245	0	0	_aPermethrin / _cpublished under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
260			_aGeneva : _bWorld Health Organization, _c1990.
300			_a125 p.
440		0	_aEnvironmental health criteria ; _v94
520	3		_aEvaluates the design and findings of over 250 studies concerned with the effects on human health and the environment posed by permethrin, a photostable synthetic pyrethroid insecticide marketed since 1977. Because of its strong repellent properties and effectiveness as a stomach and contact insecticide, permethrin is widely used in the protection of several agricultural crops, in the control of insects in households and on cattle, in aerial application for forest pest control, as a fog in mushroom houses, and as a wood preservative. Public health applications include the disinsection of aircraft, treatment of mosquito nets, and human lice control. In view of the uses of permethrin and its photostable properties, a section devoted to sources of human exposure concentrates on the large number of studies investigating residues in fruits, vegetables, dairy milk, and grains. Findings from laboratory studies, indicating that permethrin is highly toxic to certain beneficial insects and natural enemies of pests, are contrasted with field investigations demonstrating the transitory nature of most toxic and repellent effects on non-target species. The most extensive section reviews the findings of experimental studies conducted to assess toxicity. Paricular attention is given to differences in study design, dose, and mode of administration that can affect the validity of findings when extrapolated to humans. The final section draws upon a limited number of occupational and clinical studies to evaluate direct evidence of adverse effects on health. On the basis of this review, the book concludes that most toxic effects are transitory, that the likelihood of carcinogenic effects in humans is extremely low or non-existent, and that permethrin, when used as recommended, is not likely to present a hazard to the general public, exposed workers, or the environment.
546			_aeng rus.
550			_aWHODOC
561			_aWHO monograph
596			_a4
650	0	2	_aPyrethrins _xadverse effects _xtoxicity.
690			_aVector Control and Pesticides.
710	2		_aWorld Health Organization.
710	2		_aInternational Programme on Chemical Safety.
008			900618s1990 1 0 eng
942			_2NLM _cMONOGRAPH
999			_c11769 _d11769