TY  - BOOK
ED  - World Health Organization.
ED  - International Programme on Chemical Safety.
TI  - Diaminotoluenes
SN  - 9241542748
PY  - 1987///
CY  - Geneva
PB  - World Health Organization
KW  - Phenylenediamines
N2  - Evaluates the risks to human health and the environment posed by diaminotoluenes. Classed as toxic, highly irritant chemicals, diaminotoluenes are large-volume intermediates used in the production of a wide variety of industrial and consumer products, ranging from dyes and corrosion inhibitors to photographic developers. The most extensive section considers the design and findings of studies conducted in experimental animals and in vitro test systems. A review of toxic effects observed with different exposures is followed by an analysis of data demonstrating that diaminotoluenes impair spermatogenesis in experimental animals and are embryotoxic and teratogenic. Documented effects on man include severe dermatitis, blistering, and urticaria and, in the eye, lachrymation, corneal opacities, and permanent blindness, if untreated. The book concludes that diaminotoluenes should be handled as hazardous chemicals and that preventive measures should be taken to protect workers and avoid environmental pollution
ER  -