TY - BOOK ED - International Programme on Chemical Safety. ED - Commission of the European Communities. ED - United Nations Environment Programme. ED - International Labour Organization. ED - World Health Organization. TI - Principles for evaluating health risks from chemicals during infancy and early childhood: the need for a special approach SN - 9241542594 PY - 1986/// CY - Geneva PB - World Health Organization KW - Chemicals KW - adverse effects KW - in infancy and childhood KW - Health status indicators KW - Environmental exposure N1 - chi of nos. 35, 36, 37, 38, 46, 47 and 59 published in one volume by: Beijing : Chinese Academy of Preventive Medicine; Bibliography: p.53-66 N2 - Elaborates basic principles for the evaluation of chemical toxicology that are specific to the physiological characteristics of infants and young children. Principles of evaluation, which were worked out by 46 leading experts, are based on a thorough review of data on postnatal physiology, metabolism, and the special factors governing exposure in this age group, including behavioural and cultural conditions. Following background information on relevant features of postnatal morphology, biochemistry, and physiology, chapters assess the kinetics of absorption, biotransformation, and elimination and point out ways in which certain conditions of postnatal development will influence the effects of chemicals on different organs and systems. The book concludes with a discussion of factors that can assist in the identification of children at risk ER -