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Dimethylformamide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by A. Bainova.

Contributor(s): World Health Organization | International Programme on Chemical SafetyMaterial type: TextTextSeries: Environmental health criteria ; 114Publication details: Geneva : World Health Organization, 1991. Description: 124 pISBN: 9241571144Subject(s): Dimethylformamide -- adverse effects -- toxicity | Chemical Toxicology and CarcinogenicityNLM classification: QV 633Abstract: Evaluates risks to human health and the environment posed by the production and use of dimethylformamide, an organic solvent produced in large quantities throughout the world. Dimethylformamide is widely used in the chemical industry as a solvent, an intermediate, and an additive, with the largest quantities used in the production of acrylic fibres and polyurethanes. Dimethylformamide is also used in the production of pharmaceutical products. The opening sections outline the main sources of human and environmental exposure and review studies of the behaviour of dimethylformamide in the environment. Because of its complete solubility in water, dimethylformamide is noted to move readily through soils; accumulation in the food chain is judged unlikely. Concerning effects on organisms in the environment, the limited data available suggest low toxicity for aquatic organisms. The second half of the book reviews findings useful in determining the risks to health posed by exposure of workers and of the general population to dimethylformamide. An extensive review of findings from experimental studies reveals consistent evidence that dimethyl-formamide is a hepatotoxic agent. Both teratogenic and embryotoxic effects have been demonstrated in several species. The final section, which evaluates data from human studies, notes that symptoms associated with cases of acute accidental occupational poisoning are transient and followed by complete recovery. Biochemical signs of liver dysfunction are observed to accompany long-term repeated occupational exposure, but evidence suggesting an increased risk of certain cancers in exposed workers was judged inadequate.
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Item type Current library Call number Copy number Status Date due Barcode
Books Books WHO HQ
READING-RM
HQ SERIAL (Browse shelf(Opens below)) 1 Available 00033110
Books Books WHO HQ
BORROWABLE-COLL-STACKS
QV 633 91DI (Browse shelf(Opens below)) 2 Withdrawn 00033109

Summary and evaluation, conclusions and recommendations in French and Spanish.

Evaluates risks to human health and the environment posed by the production and use of dimethylformamide, an organic solvent produced in large quantities throughout the world. Dimethylformamide is widely used in the chemical industry as a solvent, an intermediate, and an additive, with the largest quantities used in the production of acrylic fibres and polyurethanes. Dimethylformamide is also used in the production of pharmaceutical products. The opening sections outline the main sources of human and environmental exposure and review studies of the behaviour of dimethylformamide in the environment. Because of its complete solubility in water, dimethylformamide is noted to move readily through soils; accumulation in the food chain is judged unlikely. Concerning effects on organisms in the environment, the limited data available suggest low toxicity for aquatic organisms. The second half of the book reviews findings useful in determining the risks to health posed by exposure of workers and of the general population to dimethylformamide. An extensive review of findings from experimental studies reveals consistent evidence that dimethyl-formamide is a hepatotoxic agent. Both teratogenic and embryotoxic effects have been demonstrated in several species. The final section, which evaluates data from human studies, notes that symptoms associated with cases of acute accidental occupational poisoning are transient and followed by complete recovery. Biochemical signs of liver dysfunction are observed to accompany long-term repeated occupational exposure, but evidence suggesting an increased risk of certain cancers in exposed workers was judged inadequate.

eng.

jpn.

WHODOC

WHO monograph

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