Tri-n-butyl phosphate / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization.
Material type:
TextSeries: Environmental health criteria ; 112Publication details: Geneva : World Health Organization, 1991. Description: 80 pISBN: 9241571128Subject(s): Phosphoric acid esters -- adverse effects -- toxicity | Chemical Toxicology and CarcinogenicityNLM classification: QV 627Online resources: Click here to access online Abstract: Evalutes risks to human health and the environment posed by the production and use of tri-n-butyl phosphate. Tri-n-butyl phosphate is widely used worldwide as a solvent for cellulose esters, lacquers, and natural gums, as a primary plasticizer in the manufacture of plastics and vinyl resins, in the formulation of fire-resistant aircraft hydraulic fluids, and as an antifoaming agent, mainly in paper manufacturing plants. Although tri-n-butyl phosphate has been widely detected in air, water, sediment, and biological tissues, the review notes that concentrations are usually very low. Workers involved in aircraft maintenance and exposed during the manipulation of hydraulic fluids are regarded as the largest occupational group at risk. In view of several weaknesses in available experimental data, the report was unable to reach firm conclusions concerning the risks posed by tri-n-butyl phosphate as a potential carcinogen, neurotoxic agent, or dermal sensitizer, though a neurotoxic effect comparable to organophosphate-induced delayed neuropathy was judged unlikely. The report concludes that the production and use of tri-n-butyl phosphate pose a low risk for the environment and for the general population, and that the likelihood of long-term effects in occupationally exposed workers is small.
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Translations in French and Spanish of chapters 1, 10 and 11.
Evalutes risks to human health and the environment posed by the production and use of tri-n-butyl phosphate. Tri-n-butyl phosphate is widely used worldwide as a solvent for cellulose esters, lacquers, and natural gums, as a primary plasticizer in the manufacture of plastics and vinyl resins, in the formulation of fire-resistant aircraft hydraulic fluids, and as an antifoaming agent, mainly in paper manufacturing plants. Although tri-n-butyl phosphate has been widely detected in air, water, sediment, and biological tissues, the review notes that concentrations are usually very low. Workers involved in aircraft maintenance and exposed during the manipulation of hydraulic fluids are regarded as the largest occupational group at risk. In view of several weaknesses in available experimental data, the report was unable to reach firm conclusions concerning the risks posed by tri-n-butyl phosphate as a potential carcinogen, neurotoxic agent, or dermal sensitizer, though a neurotoxic effect comparable to organophosphate-induced delayed neuropathy was judged unlikely. The report concludes that the production and use of tri-n-butyl phosphate pose a low risk for the environment and for the general population, and that the likelihood of long-term effects in occupationally exposed workers is small.
eng.
jpn.
WHODOC
WHO monograph
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