MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02936cam a2200301 4500 |
| 001 - CONTROL NUMBER |
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| control field |
9241571047 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9241571047 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
5225019056 (Russian) |
| 035 ## - |
|---|
| -- |
(Sirsi) 9241571047 |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
WA 240 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
900619s1990 1 0 eng |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Principles for the toxicological assessment of pesticide residues in food / |
| Statement of responsibility, etc. |
published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Geneva : |
| Name of publisher, distributor, etc. |
World Health Organization, |
| Date of publication, distribution, etc. |
1990. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
117 p. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
Environmental health criteria ; |
| Volume/sequential designation |
104 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Explains the principles, concepts, and definitions used by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) when assessing toxicological data on pesticide residues in food and establishing acceptable daily intakes. Intended to guide the design and interpretation of relevant toxicological studies, the book alerts readers to the multiplicity of factors, from the endocrinology of the animal species to the pharmacokinetic and pharmacodynamic properties of the pesticide, that can influence the validity of a study and determine its relevance to safety assessment. The book has twelve main chapters. Readers are first introduced to the history of JMPR and the procedures followed in safety evaluations. Subsequent chapters present principles, supported by a detailed explanation of their rationale and changes over time, governing considerations of identity, purity, and stability, the availability and quality of data, the place of human data in toxicology assessment, and the use of structure-activity relationships. The most extensive chapter, which runs some 40 pages, provides a step-by-step guide through the battery of test methodologies currently used in the safety assessment of pesticide residues. Both classical experiments and very new tests in the fields of immunotoxicity and behavioural toxicity are critically reviewed in terms of their capacity to contribute to the safety assessment. Other chapters explain principles governing the extrapolation of animal data to humans, the allocation of an acceptable daily intake, the evaluation of mixtures, and the re-evaluation of pesticides. The book concludes with a discussion of principles for dealing with microbial pest-control agents and bioengineered organisms, followed by advice on the special methodological problems posed by the organophosphates, bipyridilium compounds, and goitrogenic carcinogens. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
chi eng rus. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
jpn. |
| 550 ## - ISSUING BODY NOTE |
|---|
| Issuing body note |
WHODOC |
| 561 ## - OWNERSHIP AND CUSTODIAL HISTORY |
|---|
| History |
WHO monograph |
| 596 ## - |
|---|
| -- |
4 |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pesticide residues |
| General subdivision |
analysis |
| -- |
toxicity. |
| 650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Food contamination. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) |
|---|
| Topical term or geographic name as entry element |
Chemical Toxicology and Carcinogenicity. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
International Programme on Chemical Safety. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
World Health Organization. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
NLM Classification Scheme |
| Koha item type |
Books |
